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25-Sep-2018 09:19:06 am

How does the Drug Gabapentin Work in the Body?Posted by Admin

how does the drug gabapentin work in the body 1537867146

Gabapentin interacts with the cortical neurons present at the auxiliary subunits of the calcium channels that are voltage- sensitive. The drug is responsible for the increase in the synaptic concentration of GABA and also enhances the response of GABA at the non- synaptic sites in the neuronal tissues causing a reduction in the release of the monoamine neurotransmitters. Another action which is implicated in the mechanism of gabapentin drug is the reduction of axon excitability which can be measured as a change in the amplitude of the presynaptic fiber volley (FV) in the CA1 spot of the hippocampus. This is done by binding itself to the presynaptic NMDA receptors. Gabapentin 100mg capsule bind and activated the adenosine A1 receptors. 

Gabapentin 300 mg for pain is used in the capacity of the anti-convulsing drugs to treat amyotrophic lateral sclerosis (ALS), partial seizures, and severe neuropathies. It is also used in the treatment of tremor, mood disorders, refractory partial seizures, multiple sclerosis, and disruptive behavior which is seen in dementia.

The drug has high lipid solubility and is not metabolized by the liver. It does not bind to the protein and very fewer drug interactions. It is eliminated from the body and the systemic circulation through renal excretion as an unchanged drug, It is not metabolized in the human body. However, it is not suitable to be taken along with alcohol. The Neurontin side effects (Neurontin is the brand name of gabapentin) are very rare.

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